Top 18 Natural Anti-Inflammatory Supplements

3D illustration of the human body depicting common points of inflammation

Understanding Inflammation

Inflammation is the body’s innate response to injury or infection, a protective measure designed to eliminate the cause of cell damage, clear out the debris, and repair the affected tissue.

However, when this inflammatory response goes awry, refusing to subside, it becomes chronic – potentially causing a range of conditions, including autoimmune disorders, heart disease, stroke, and metabolic syndromes like diabetes. Even more insidiously, it operates under the radar, often without noticeable symptoms until a disease state has been reached.

The link between chronic inflammation and these diseases is complex and multi-faceted. At its core, it involves an overactive immune system, which, instead of defending against foreign pathogens, begins to attack the body’s own tissues. This can be triggered by a variety of factors: persistent infections, long-term exposure to irritants, genetic predispositions, or lifestyle choices such as a diet high in processed foods.

Fortunately, nature’s apothecary is brimming with compounds that have stood the test of time and now, the scrutiny of science. Natural anti-inflammatory supplements promise a gentler approach, working in concert with the body’s own rhythms to dial down the chronic hum of inflammation.

Here are 18 supplements that research suggests may help to reduce inflammation in the body.

1. Curcumin

Curcumin, the vibrant yellow-orange pigment found in turmeric, isn’t just a staple in the spice cabinet for its flavor. It’s a compound that has been revered in traditional medicine and is gaining acclaim in the scientific community for its anti-inflammatory properties.

It’s thought to work by blocking certain enzymes and cytokines that contribute to inflammation. Curcumin’s potential extends beyond mere symptom relief; it’s studied for its role in protecting brain health, easing joint pain, and even reducing the risk of chronic diseases.

However, it’s not without its challenges—curcumin has low bioavailability, which means the body struggles to absorb it in significant amounts. This has led to the development of specialized formulations that enhance its absorption, ensuring you can get the most out of this golden wonder.

See Also: Turmeric Vs Curcumin – What’s The Difference?

2. Omega-3 Fatty Acids

Omega-3 fatty acids are the unsung heroes of cellular health. These polyunsaturated fats, particularly found in fish, flaxseeds, and walnuts, are not just essential to our diets; they are critical modulators of inflammation.

EPA and DHA, the types of omega-3s found in fish oil, are adept at reducing the production of inflammation-promoting substances. Alpha-linolenic acid (ALA), another omega-3 found in plant sources like flaxseed, is converted by the body into EPA and DHA, albeit at a lower rate.

Incorporating these fatty acids into our diet helps to construct a more anti-inflammatory environment within the body, which is beneficial for maintaining cardiovascular health and may play a role in preventing neurodegenerative and autoimmune diseases. Omega-3s are a cornerstone of anti-inflammatory nutrition, and their widespread effects on overall health are a testament to their importance.

3. Resveratrol

Resveratrol could be considered the fountain of youth hidden in plain sight within red wine, grapes, and berries. This potent antioxidant not only combats oxidative stress but also modulates inflammation. It interferes with the signals that tell the body to inflame tissues, thereby acting as a brake on the inflammatory process.

Its benefits are far-reaching, with research exploring its impact on heart health, longevity, and even neurological resilience. The intrigue of resveratrol lies in its ability to potentially mimic the effects of caloric restriction, a known strategy for extending lifespan in various organisms.

Yet, similar to curcumin, resveratrol’s bioavailability is a hurdle, prompting the use of supplements to achieve therapeutic concentrations in the body.

4. Ginger

Ginger, with its zesty and warming presence, is more than just a culinary delight; it’s a botanical remedy with a rich history of medicinal use, particularly for quelling nausea and soothing upset stomachs. But the scope of ginger’s virtuosity extends to the realm of inflammation.

The root is packed with gingerol, a bioactive compound that shares pharmacological properties with non-steroidal anti-inflammatory drugs, but without the harsh side effects. Ginger has been shown to inhibit the synthesis of pro-inflammatory cytokines, providing a natural means to manage conditions like osteoarthritis.

Its efficacy is not just rooted in tradition but is increasingly validated by scientific studies that highlight its anti-inflammatory and antioxidative effects, making it a worthy contender in the fight against chronic inflammation.

5. Zinc

Zinc is a trace mineral with a mighty role in the body’s defensive lineup. It’s best known for its immune-boosting prowess, but zinc also has a significant role in controlling inflammation. It works by impacting various inflammatory pathways and stabilizing cell membrane structure, which can prevent the out-of-control inflammation that characterizes many chronic diseases.

Zinc’s balancing act is crucial for maintaining the body’s immune response without letting it tip over into chronic inflammation. Given its involvement in numerous enzymatic reactions and cellular metabolism, a deficiency in zinc can lead to a weakened immune system and an increased inflammatory state.

Ensuring adequate zinc intake through diet or supplements can thus be a strategic move in managing inflammation and supporting overall health.

6. Frankincense

Frankincense, also known as Boswellia serrata resin, has been shown to have potential benefits in relieving both inflammation and pain.

Studies suggest that frankincense may help reduce cartilage loss and even reverse symptoms of autoimmune conditions. According to the Arthritis Foundation, it is considered a fast-acting supplement that can provide relief from osteoarthritis pain in as little as 7 days.

The recommended dosage is an extract containing 30-40% boswellic acids, taken in doses of 250-500 mg two to three times a day. Combining frankincense with curcumin may enhance its effectiveness.

Overall, frankincense is generally safe to use and has minimal side effects. However, some individuals may experience stomach pain or gastrointestinal issues like diarrhea.

7. Quercetin

A flavonoid that is abundant in apples, onions, and other plant foods, quercetin is known for its antioxidant activity. Research has demonstrated its potential in reducing inflammation and blood pressure in hypertensive subjects.

8. Bromelain

Bromelain is an enzyme that naturally occurs in pineapple, specifically in the fruit and stems. The National Center for Complementary and Integrative Health notes this fact.

While bromelain is believed to offer various health benefits, such as aiding in inflammation and pain relief, the exact mechanisms behind these effects are not fully understood.

In a study involving 103 individuals with osteoarthritis (OA), a group of 52 participants received a bromelain-containing mixture, while the remaining 51 were treated with diclofenac, a medication prescribed for inflammation (NSAIDs). The results demonstrated the bromelain-containing mixture to be a safe and effective alternative to NSAIDs for managing painful episodes of knee OA.

9. Alpha-lipoic Acid

This antioxidant plays a key role in metabolism and energy production. It also has anti-inflammatory effects and is being investigated for its potential in reducing heart disease risk factors and managing type 2 diabetes.

10. Spirulina

Spirulina is a type of blue-green algae that possesses powerful antioxidant properties. Multiple studies have indicated that it can reduce inflammation, support healthy aging, and potentially enhance the immune system.

While most of the research on spirulina has focused on its effects in animal studies, studies conducted on older adults have demonstrated potential improvements in inflammatory markers, anemia, and immune function.

Consuming up to 8 grams of spirulina per day is considered safe, and many individuals choose to incorporate it into their shakes or smoothies since it is available in powder form.

There are currently no significant known side effects associated with spirulina. However, individuals with autoimmune conditions may want to exercise caution and avoid its consumption as it has the potential to worsen their condition due to its immune-strengthening properties.

11. S-adenosylmethionine

S-adenosylmethionine (SAM-e) is a natural substance produced by the body that plays a crucial role in regulating genes through epigenetic factors. These factors influence gene expression and behavior by turning certain genes on or off, and altering their effects.

In some cases, doctors may recommend SAM-e to alleviate symptoms of depression, osteoarthritis, and specific liver conditions, as inflammation may contribute to these conditions.

Clinical trials have suggested that SAM-e could potentially provide relief from pain and inflammation associated with different forms of arthritis, sometimes comparable to the effectiveness of NSAIDs.

The appropriate dosage of SAM-e varies depending on the individual’s condition, and it’s important to note that SAM-e may interact with various medications. Therefore, it is essential to consult a doctor before starting any treatment with SAM-e.

12. N-Acetyl Cysteine with Glutathione

N-acetyl cysteine (NAC) is a compound derived from the amino acid L-cysteine, which is a building block of protein. It is believed to possess antioxidant properties.

According to Elise Quinlan, a registered dietitian and owner of Eat With Elise in Philadelphia, Pennsylvania, one of the main roles of NAC in the body is acting as a precursor to glutathione. Glutathione is a potent antioxidant that helps combat oxidative stress.

When glutathione levels are depleted, it is believed that the body may become more susceptible to chronic inflammation and the progression of diseases. While it is not clear whether there are additional benefits in taking NAC and glutathione in combination, supplementing with at least one of them may have anti-inflammatory effects, as highlighted by Quinlan.

13. Garlic

Garlic is a common food that contains powerful anti-inflammatory compounds, similar to ginger, pineapple, and fatty fish.

One of the key compounds found in garlic is allicin, which acts as a potent anti-inflammatory agent. It is also believed to contribute to strengthening the immune system, helping to combat disease-causing pathogens.

In a well-conducted study, 51 adults with obesity were given either 3.6 grams of aged garlic extract or a placebo daily for 6 weeks. The researchers observed significant improvements in the inflammatory markers TNF-α and IL-6.

There is a hypothesis that long-term supplementation with aged garlic may reduce the risk of chronic diseases associated with inflammation.

Garlic supplements are available in various dosages, all of which are generally safe with minimal side effects (apart from the well-known garlic breath). Consuming just 2 grams of fresh garlic daily, which is approximately one clove, can also provide some anti-inflammatory benefits.

14. Vitamin D

Vitamin D is an essential nutrient that is soluble in fat and plays a crucial role in supporting immune health. It is also believed to possess potent anti-inflammatory properties.

Numerous studies have observed a correlation between low levels of vitamin D and the presence of inflammation.

A well-conducted study involving 44 women with premenstrual syndrome and low vitamin D levels found that taking 50,000 International Units (IU) of vitamin D every 20 days for 4 months resulted in reduced inflammation compared to a control group.

Similar findings have been reported in individuals who have both vitamin D deficiency and obesity.

It is important to note that in the long term, adults should not exceed a daily intake of 4,000 IU. Fat-soluble vitamins such as vitamins A, D, E, and K can accumulate in fat cells over time, potentially leading to toxicity.

15. Caspsaicin

Cayenne pepper, which belongs to the Capsicum annuum species, is known for its abundance of antioxidant compounds that may play a role in managing inflammation within the body.

Particularly, capsaicin, a plant-based compound found in the fruit of this pepper, has been associated with pain and swelling relief, as well as reducing inflammation.

According to Anderson-Haynes, a review study revealed that both animal and human studies indicated that red peppers, including Capsicum annuum, were effective in controlling metabolic disorders associated with chronic inflammation. This was achieved by significantly reducing cholesterol levels and improving insulin utilization within the body.

16. Vitamin C

Vitamin C is an essential vitamin that, similar to vitamin D, plays a significant role in both immunity and inflammation. It acts as a potent antioxidant, neutralizing free radicals that can cause cellular damage and inflammation.

Furthermore, it supports the optimal functioning of the immune system, which in turn helps regulate inflammation since inflammation is closely tied to immune responses.

In hospitalized patients with severe respiratory illnesses such as influenza, pneumonia, and even COVID-19, high doses of vitamin C are often administered intravenously to assist in reducing inflammation.

For healthy individuals, doses exceeding 2,000 mg of vitamin C may result in diarrhea. Apart from that, vitamin C supplements are generally safe with minimal side effects.

However, it’s worth noting that meeting your vitamin C requirements solely through a balanced diet is easily achievable, as there are a variety of fruits and vegetables in green, red, orange, and yellow hues that serve as rich sources of this nutrient.

17. Cat’s Claw

Cat’s claw is derived from different uncaria plants, such as Uncaria tomentosa and Uncaria guianensis.

Studies indicate that cat’s claw may have the ability to reduce various types of inflammation. It is particularly effective in inhibiting TNF-alpha, which is an inflammatory chemical produced by the body.

While cat’s claw is generally considered safe for use, there is an older case report suggesting a potential risk of kidney failure in individuals with lupus. It may also cause nausea, although an older animal study suggested that it might offer protection against gut inflammation caused by the NSAID indomethacin.

18. Sulphoraphane

Sulforaphane, which is naturally found in foods such as broccoli or Brussels sprouts, offers more significant benefits when consumed as a supplement due to limitations with food preparation and consumption, according to Quinlan.

Studies suggest that sulforaphane aids in reducing pro-inflammatory cytokines and decreasing oxidative stress.

Lifestyle and Diet Considerations

While supplements can play a significant role in managing inflammation, they are most effective when paired with a healthy lifestyle and diet. Inflammation doesn’t exist in a vacuum; it’s profoundly influenced by how we live and what we consume.

This section explores the foundational changes we can make to our daily routines to create an environment less conducive to inflammation.

Dietary Choices

A diet rich in whole foods is the first line of defense against chronic inflammation. Foods that are high in fiber, antioxidants, and healthy fats act as natural anti-inflammatory agents. These include leafy greens, nuts, seeds, fatty fish, and brightly colored fruits and vegetables.

On the flip side, a diet heavy in processed foods, sugars, and trans fats can fuel the inflammatory fire. By shifting our focus to a Mediterranean-style diet, which emphasizes these anti-inflammatory foods, we can make a profound impact on our inflammation levels.

Physical Activity

Regular exercise is another pillar of an anti-inflammatory lifestyle. It can help reduce inflammation by improving circulation, reducing fat stores that release inflammatory cytokines, and promoting the release of anti-inflammatory chemicals in the body. It doesn’t require strenuous activity; even moderate, consistent exercise like walking or yoga can yield benefits.

Stress Management

Chronic stress is a known contributor to inflammation. The constant release of stress hormones can keep the body in a state of high alert, leading to an overactive immune response. Techniques such as mindfulness, meditation, deep breathing exercises, and sufficient sleep are effective ways to manage stress and, by extension, inflammation.

Avoiding Toxins

Exposure to environmental toxins—like smoke, pollution, and certain chemicals—can also trigger an inflammatory response. Limiting exposure by choosing clean personal care products, reducing plastic use, and avoiding smoking can help minimize this risk.


Adequate hydration is essential for all bodily functions, including the immune system’s ability to fight inflammation. Water helps flush out toxins that can contribute to inflammation, supports kidney function, and aids in nutrient transport to cells.

Healthy Relationships and Community

A supportive social network and positive interpersonal relationships can influence our health in profound ways, including reducing stress and inflammation. Engaging in community activities, fostering strong friendships, and seeking support when needed can enhance our overall well-being.

By integrating these lifestyle and diet considerations into our daily routine, we create a comprehensive approach to managing inflammation. Supplements are a valuable tool, but they are most effective when combined with these foundational health practices. Together, they can synergistically reduce inflammation and promote a healthier, more vibrant life.


Each of these supplements comes with its own set of guidelines for use and potential interactions with other medications. They are not cure-alls but could potentially be integrated into a holistic approach to health, complementing other lifestyle measures such as a balanced diet and regular exercise.

Before considering any of these supplements, it is essential to consult with a healthcare professional, particularly if you have underlying health conditions or are taking other medications.



Please follow and like us:

Leave a Comment

Your email address will not be published. Required fields are marked *

Scroll to Top