The Top 5 Anti-Aging Supplements That Really Work

Anti-Aging Supplements

The Best Anti-Aging Supplements of 2024 – Quick View

GenF20 Plus product photo

#1: GenF20 Plus

Rating Stars: 5/5

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GenFX container and pill

#2: GenFX

Rating Stars: 4/4.5

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Phyto350 product image

#3: Phyto 350

Rating Stars: 4/4.5

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MitoTrax product photo

#4: MitoTrax

Rating Stars: 4/5

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Collagen Complex product image

#5: Collagen Complex

Rating Stars: 4/5

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Throughout human history, people have been looking for methods to restore youth and slow the aging process. But the search for the elusive fountain of youth is as strong as ever, with an entire anti-aging supplement industry offering out a wide range of pills, lotions, serums and other anti-aging products, all intended to turn back the hands of time.

However, these products often have a  hefty price tag attached, and with all the options available it can be a huge task just trying to figure out which ones actually work.

If you find yourself wondering which vitamins and supplements can actually help you to look and feel younger, you’ve come to the right place. In this article, I’ll be covering everything you need to know about anti-aging supplements, including which actually help slow down and even reverse the signs of aging, allowing to look and feel your youngest.

Benefits of Anti-Aging Supplements

Many people associate anti-aging supplements with skin-care products and creams that are designed to reduce the visible signs of aging by diminishing lines and wrinkles, removing age spots, and keeping skin smooth and supple. But the benefits offered by anti-aging supplements go far beyond the exterior.

In fact, they help with reducing many symptoms associated with aging that might not even be seen by the naked eye. To name just a few of the potential benefits that anti-aging supplements can offer:

  • Smoother, more elastic skin
  • Increased muscle tone
  • Better vision
  • Improved bone density
  • Greater energy levels
  • Relief from joint pain
  • Improved cardiovascular health
  • Enhances exercise and overall fitness
  • Boosted immune function

We can generally classify anti-aging supplements into three categories:

  • Supplements specifically formulated to deliver anti-aging benefits
  • Hormone-supporting supplements that help restore youthful levels HGH.
  • Vitamins that have shown to provide anti-aging benefits

The best supplements will be made of a combination of two or all three of these types.

The Top 5 Anti-Aging Supplements – Product Details

#1. GenF20 Plus

GenF20 Plus tablets box and spray bottle on white background


GenF20 Plus is our number one pick for its remarkable anti-aging benefits. This amazing HGH supplement demonstrated the greatest success rate while delivering noticeable results for virtually every single user that we surveyed.

GenF20 Plus works by safely, naturally, and effectively increasing your body’s own production of human growth hormone – referred to by many as the “Fountain of Youth”. Here are some of the benefits that are consistently being reported by users of this cutting-edge anti-aging supplement system:

  • Tighter, firmer skin
  • Reduced appearance of wrinkles
  • Improved muscle tone
  • Rapid fat loss
  • Increased metabolism
  • More youthful energy levels
  • Renewed libido
  • Enhanced immune system

Most (if not all) of these effects were reported by every respondent who participated in our survey. We found that one reason for its high rate of success is due to its state-of-the-art formula, which provides a far greater dose of active ingredients when compared to most of the other supplements we tested.

Another reason why the GenF20 Plus system works so well is because it delivers its dosages through both a pill and an oral spray. The benefit of applying this type of two-pronged delivery is a super-efficient absorption of ingredients that will unavoidably trigger age-reversing physiological changes in the body.

Combine these benefits with the reasonable value in price, discounts for ordering multiple packages, and a more-than-fair 67-day money-back guarantee, and GenF20 Plus is one of the best HGH supplements I’ve reviewed, and it’s a complete no-brainer for anyone wanting to turn back the clock on their body’s biological aging process. HIGHLY recommended.

Be sure to check out my full GenF20 review for more in-depth details.

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#2. GenFX



Another powerful and effective anti-aging supplement, GenFX has been steadily growing in popularity ever since it was first introduced into the market.

Although advertisement and marketing for this HGH supplement has been minimal, it has nevertheless become extremely popular in the anti-aging community, with full endorsements by cosmetic surgeon and certified obstetrician Dr. Dave David, and Ph.D. in Biomedical Sciences, Dr. Karen Vieira.

GenFX naturally and safely increases the healthy production of HGH in the body, leading to the reduction of the age-related symptoms associated with low levels of growth hormone, such as:

  • Weight gain
  • Loss of sex drive
  • Loose, sagging skin
  • Diminished muscle tone
  • Wrinkles of the face and hands
  • Poor memory and mental function
  • Difficulty sleeping
  • Declining bone health

Do these symptoms sound familiar? GenFX was scientifically formulated to combat the unpleasant side-effects of aging, gradually allowing you to look and feel years younger.

Research and testing of this product revealed a potent and effective ingredient profile, and a remarkably consistent success rate among the vast majority of respondents who used GenFX. We have also noted an extremely high rate of customer satisfaction and marks for product quality and effectiveness.

Additionally, many of those taking GenFX have observed results in just 10 days. However, to fully see and feel the greatest changes it’s recommended to use the product consistently for a period of no less than 90 days.

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3. Phyto350

Phyto 350 bottle and capsules


Phyto350 is an anti-aging supplement by Dr. Dave David of Skinception, a hugely popular, premium skin-care product company. This high-quality supplement is made with an advanced phytoceramides formula that’s so effective, it’s like having a facelift in a bottle.

Most people will experience up to a 40% reduction in their skin’s structure as they age. This is one of the reasons why wrinkles form and we develop a visibly older appearance Phyto350 replaces these crucial structures, called ceramides, rejuvenating the look and feel of your skin.

Ceramides are lipids that occur naturally in the skin and diminish with age. Phyto350 is packed with super-potent phytoceramides, which are plant-derived ceramides.

Once these molecules absorb into your bloodstream, they immediately help to rebuild damaged skin, similar to putting mortar between bricks, for healthier skin. By replacing these lost ceramides back into your skin, you will experience a complexion that’s visibly younger, smoother, and healthier – from the inside-out.

And since it’s taken as a supplement instead of a cream or serum, the anti-aging benefits you’ll experience with Phyto350 can even be more powerful than with a topical application -because this product goes to work internally, starting in the bloodstream. From there, it absorbs into your cells, which transport the ceramides into the inner and outer layers of your skin.

This is one of the main reasons why the results people are getting with Phyto350  are so dramatic, including:

  • Less Visible Fine Lines and Wrinkles
  • Gives a Noticeably Younger Complexion
  • Reduces Skin Blemishes
  • Repairs Sun Damage

Also packed with vitamins A, C, D, and E, Phyto350 is an internal approach to more youthful appearance – and highly effective one, as well. In fact, Dr. Oz calls ceramides a natural facelift with anti-aging benefits.

This is precisely what you’re getting with Phyto350, but none of the harmful ingredients like PEG compounds and parabens that you’re at risk of when using many drugstore wrinkle creams. If you’re after healthy looking skin, or want a boost to any topical products you’re already using, Phyto350 is a must-try – you won’t be disappointed!

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4. MitoTrax

MitoTrax bottle front label


MitoTrax is a is the most sophisticated mitochondrial enhancement supplement on the market, and is a major player when it comes to what we know about cellular health and anti-aging. The formula used in MitoTrax is at the cutting-edge of cellular research, and contains all 4 of the recommended supplements for strong mitochondria, healthy aging, cognitive enhancement, and all-day energy.

Mitochondria are special structures in our cells that act as batteries, fueling various functions of the cell and the body overall. Often referred to as the “powerhouses of the cell”, mitochondria help turn the energy we get from food into energy that the cells can use.

When the mitochondria are operating at peak performance, all of the body’s cells are also operating at peak performance, improving all of the bodies processes.

MitoTrax is the most comprehensive mitochondrial supplement, containing important minerals, nutrients, vitamins, and supplements to help boost the effects of the overall formula. It’s the only supplement currently available that’s based on the most recent research into maintaining a younger, more vibrant and energetic you – despite the reduced mitochondrial function that occurs normally with aging.

Every dose revitalizes your body and helps to turn back your biological clock by:

  • Enhancing mitochondrial function (the powerhouses of your cells)
  • Protecting against age-related deterioration
  • Rejuvenating your system with vitamins and minerals
  • Boosting energy levels
  • Promoting healthy brain function for a clear, sharp mind

Scientific research has identified four ingredients that support healthy mitochondrial function, and MitoTrax is formulated with precise doses of all of them: CoQ10, BioPQQ, ALA, and Acetyl L-Carnitine. Also included are powerful neural health ingredients that have shown demonstrated amazing benefits for mitochondrial and nerve growth, which could have huge implications for short- and long-term memory protection.

MitoTrax is a new and exciting product that is on the cutting edge of anti-aging supplementation. If you’re serious about rejuvenation, whether it be for a youthful appearance, energy, brain function, or your overall health, this is one anti-aging supplement you should definitely be adding to your regimen.


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5. VitaPost Collagen Complex

Collagen Complex bottle and front label on white background


VitaPost Collagen Complex is a premium collagen protein supplement that rejuvenates skin, joint, and bone health. Containing precise amounts of a high-quality collagen complex, gelatin and magnesium stearate,  this supplement will quickly restore that gorgeous, youthful glow that you can see and feel.

Are you aware of the wonderful benefits of Collagen? Collagen is the most abundant protein in your body, and it plays a major role in the health of your skin, bones, teeth, muscles, tendons and ligaments. VitaPost’s Collagen Complex repairs, protects, and revitalizes your skin – reducing fine lines, wrinkles, and dark spots, while improving firmness.

Collagen Complex also helps keep the cartilage in your joints supple. It also supports the health of your arteries, keeping them strong and flexible. It strengthens bones, as well, by helping to reinforce their structure.

  • Supports your skin, hair, nails, bone and joint health.
  • Promotes healthy digestive function
  • Helps protect your cardiovascular system
  • Promotes a more youthful, healthy-looking skin.
  • Formulated with hydrolyzed collagen for higher absorption

If you’re not taking collagen as part of your anti-aging routine, you should be. VitaPost Collagen Complex is a high-grade supplement of superior quality, that will help to bring back that youthful glow to your skin, hair, and nails, and have you looking and feeling years younger.

Not only that, it nourishes skin and reduces inflammation from the inside-out for a more even skin tone. VitaPost Collagen Complex is formulated to do all that and more.


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Other Anti-Aging Supplements

Hormone Support Supplements

HGH Supplements

Human growth hormone, also called HGH or GH, is a peptide hormone that stimulates growth cell reproduction and regeneration in humans. It’s produced in the pituitary gland and is regulated by your hypothalamus. HGH serves a primary role in development during childhood and adolescence.

Later in life, human growth hormone still plays an important role in general health, such as regulating your metabolism, bone density, muscle mass, and even your ability to burn body fat. Unfortunately, the amount of growth hormone our bodies produce declines as we age.

With this decline comes an increased risk of certain health problems, like cardiovascular disease, osteoporosis, and even depression. In addition to these general health risks, low GH production in adults can promote weight gain, especially in your abdomen area.

Low levels of HGH can be increased by doctor-administered injections, or with HGH supplements. Natural human growth hormone supplements work by stimulating either the pituitary gland directly to produce more of your own growth hormone, or the hypothalamus portion of your brain to signal the pituitary gland to produce more HGH.

Testosterone Supplements

Libido in both men and women is primarily driven by testosterone, which diminishes with age affecting both sexes. Testosterone is also critical for retaining muscle mass, strength, and bone health. Testosterone is commonly treated with injections and topical creams, but natural testosterone supplements are also an excellent alternative.

Estrogen and Progesterone Supplements

Estrogen and progesterone are female hormones crucial for maintaining several important functions in the body, including: strength, sex drive, cognitive function, and in counteracting the effects of menopause. The latest research suggests that estrogen could be effective as a treatment for age-related memory problems.

Estrogen and progesterone can be supplemented in several ways, including with prescription-based injections, creams, and drugs, as well as natural menopause supplements. Of particular interest is the use of plant-based phytoestrogens, which have safe (although limited) estrogenic effects, as a potential substitue for prescription forms of estrogen.


Dehydroepiandrosterone, or DHEA, is a hormone produced by the adrenal glands and plays an important role in the creation of steroid hormones like testosterone and estrogen. DHEA production diminishes swiftly with age in both men and women.

DHEA gained credibility in the scientific community when the book “DHEA and Aging” was published by the New York Academy of Sciences . This publication offered scientific evidence for several of the longevity benefits linked with DHEA.

DHEA supplementation is popular among individuals looking to boost physical performance, build muscle, and to help slow down the aging process.


Commonly referred to as the “mother hormone”, Pregnenolone is a precursor for several important hormones, including testosterone, estrogen, and DHEA. Classified as a neurosteroid, there is evidence to suggest that Pregnenolone has an enhancing effect on memory.


Melatonin is a hormone produced by the pineal gland, a small endocrine gland situated in the middle of the brain. Melatonin is a very powerful antioxidant, and has been referred to as the “pacemaker” of the aging clock in humans.

Melatonin gets released nightly and is important for maintaining our biological rhythms for sleep and recovery from fatigue. Scientific research points to the importance of keeping melatonin at youthful levels in order to protect against the degenerative diseases associated with aging.

See Also: Melatonin: The Sleep Hormone With Surprising Superpowers

Acetyl-L-Carnitine Arginate

Acetyl-L-carnitine is an amino acid that is found in most cells in the body, including brain, nerves, heart, liver and sperm cells, where it increases the production of energy in the mitochondria. Research studies have demonstrated that acetyl-L-carnitine provides many benefits itself, but since the discovery of acetyl-L-carnitine arginate, these same benefits were greatly enhanced.

This patented form of carnitine triggers the growth of neurites in the brain. Research shows that acetyl-l-carnitine-arginate triggers the growth of new neurites by an amazing 19.5%, which is almost four times better than acetyl-L-carnitine alone.

Acetyl-L-carnitine arginate is excellent for improving mood, learning, and memory. It also helps your muscle cell mitochondria burn fat, which can boost your endurance and physical performance, and help you recover faster.


In the U.S., the most common causes of death and disability are heart attacks and strokes brought about by an abnormal blood clot formed inside an artery of the heart or brain. Aspirin restricts the formation of enzymes called prostaglandins, which encourage blood cells to stick together to form clots.

By blocking prostaglandins , aspirin produces an immediate and lasting effect on blood platelets, making them less likely to clump together and making blood flow smoothly.


Carnosine is a a compound made up of two linked amino acids (alanine and histidine), and is naturally produced by the body. In humans, high concentrations of carnosine are found in muscle tissue and in the brain.

Carnosine can also be obtained from foods, with large amounts found in beef and fish, and in lower amounts in chicken. In fact, levels of carnosine found in muscle tissue correlate with the maximum life spans of animals.

Carnosine levels diminish with age. Muscle levels decrease by 63% by age 70, which could explain the decrease in muscle mass and function typically associated with age. Carnosine protects muscle cell membranes and allows the heart to contract more efficiently.

Carnosine is unique in that it also interferes with the process of glycation, which is a major contributor to wrinkled skin and other age-related health conditions, such as  neurologic, vascular, and eye disorders.


CoQ10 (Coenzyme Q10) is necessary for the healthy function of the mitochondria and helps convert fats and sugars into energy. Aging individuals have been found to have on average over 50% less CoQ10 than young adults.

Approximately 95% of our cells’ energy is produced in the mitochondria, which are the “energy powerhouses” of the cells. Mitochondrial disorders are associated with many health conditions, and an increasing amount of scientific research show a link between age-related mitochondrial disorders and a deficiency of CoQ10.

For individuals over the age of 30, these findings make CoQ10 one of the most important nutrients to supplement with.

Fish Oil

Research conducted on omega-3 fatty acids is so impressive that National Institutes of Health published a study showing that fish oil can help prevent deaths associated with heart disease. Even the FDA has recognized that consuming EPA and DHA omega-3’s could decrease the likelihood of developing coronary heart disease.

Among the multiple actions that are attributed to the positive benefits connected with fish oil are its ability to lower triglyceride levels (which helps decrease the risk of heart and blood vessel disorders), and its  ability to protect the healthy flow of blood in the arteries.

Green Tea Extract

Green tea extract has a large amount of published research studies that verify its many health benefits. The most important findings are from studies demonstrating that green tea extract assists in maintaining cellular DNA and membrane integrity.

After years of research, we’ve learned that green tea contains powerful antioxidants called polyphenols, catechins, and flavonols. A number of catechins are found in green tea and are responsible for the majority of the favorable research findings.

Of these catechins, EGCG (epigallocatechin gallate) is the most potent. EGCG is an antioxidant that is around 25-100 times more powerful than vitamins C and E. A single cup of green tea can provide as much as 10-40 mg of polyphenols, providing greater antioxidant benefits than a serving of broccoli, spinach, carrots, or strawberries.

The high level of green tea’s antioxidants makes it helpful for protecting the body from the oxidative damage attributed to free radicals.


GPC, or L-alpha glycerylphosphoryl-choline, helps with the synthesis of a number of phospholipids in the brain, which boosts the availability of acetylcholine in certain brain tissues. Research shows that the GPC form of choline helps to protect against the cognitive decline typically associated with aging.

Lipoic Acid

Lipoic Acid is a very powerful antioxidant that neutralizes the effects of reactive free radicals in the mitochondria, which play a major part in human aging. Research indicates that a surplus of compounds that inhibit free-radicals (such as lipoic acid) could be effective in slowing down the aging process.

Lipoic acid is also able to convert other antioxidants like Vitamin C back into their original state after neutralizing free radicals. Research also indicates that lipoic acid can decrease glycation damage from excess amounts of blood glucose, which could play a role in aging.


In the past, the only choices available for aging people wanting to restore diminishing numbers of mitochondria (the cell’s “energy powerhouses”) were exercise to the point of exhaustion, or undergoing a long-term calorie restricted diet. Obviously, these methods will not prove easy or practical for most aging individuals.

These days there’s a far more agreeable alternative. PQQ (pyrroloquinoline quinone) stimulates genes that encourage the creation of new mitochondria.

PQQ also interacts in a beneficial way with genes directly tied to mitochondrial health. These genes also help to support the healthy metabolism of fat and sugar, maintain normal body weight, and increase cell production.


Evidence from published research studies show that resveratrol could be the most effective substance for supporting optimal health and increasing longevity. Classified as a phytoalexin, resveratrol is a polyphenolic compound concentrated mostly in the skins and seeds of grapes and berries.

Additional studies show that many of the positive changes in gene expression seen in calorie-restricted diets were observed when resveratrol was combined in low doses with grapeseed extract. But other research indicates that larger doses might be necessary to experience all of the health benefits associated with resveratrol,

Some of these benefits include: improved insulin sensitivity, enhanced function of the mitochondria, decreased inflammation in the body, and protection from the negative effects associated with a high-fat diet.

Whey Protein

Whey protein is often considered to be a supplements best suited for athletes and bodybuilders to help increase muscle mass. However, increasing evidence indicates that certain BCAA’s, or “branched-chain amino acids“, can imitate the life-extending benefits of calorie restriction. Primarily, these include leucine, ioleucine, and valine.

Whey protein is also believed to positively affect immunity and muscle fitness because of the BCAA’s it contains, as well as its lactoferrin and immunoglobin content.

Folic Acid and Vitamins B6 and B12

Homocysteine a nonessential, sulfur-containing amino acid, is an independent marker of risk for the development of cardiovascular disease. Back in 1981, we first recommended that customers reduce homocysteine levels by taking folic acid, vitamin B6, and vitamin B12.

Homocysteine can make blood clot more easily than normal, increasing the risk of both heart attack and death by heart attack. Inadequate levels of folic acid and vitamins B6 and B12 can lead to increased homocysteine levels.

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